Myrtus communis L. Extract Ameliorates High Fat Diet Induced Kidney and Bladder Damage by Inhibiting Oxidative Stress and Inflammation

Objective: Obesity is associated with many diseases, including urinary system disorders such as chronic kidney disease and overactive bladder syndrome. Myrtus communis L. (MC) extract has been reported to have antioxidant anti-inflammatory effects. The aim of this study was investigate the protective effects MC on high-fat diet (HFD)-induced damage. Materials Methods: Wistar albino male rats were divided into three experimental groups: control, HFD HFD+MC. Experimental groups fed a standard (control group) or (HFD HFD+MC groups) for 16 weeks. (100 mg/kg) administered group orally during last 4 weeks (5 days/week) experiment. Highdensity lipoprotein, total cholesterol, triglyceride leptin levels measured in blood serum. Tissue malondialdehyde (MDA), glutathione (GSH), 8-hydroxy-2'-deoxyguanosine (8-OHdG) myeloperoxidase (MPO) evaluated biochemically. Kidney morphology, NADPH oxidase-2 (NOX-2) nuclear factor-kappa B (NF-ҡB)-positive apoptotic cells histologically. Results: Lipid profiles altered increased MDA, 8-OHdG MPO GSH level decreased group. Moreover, degenerated NOX-2 NF-ҡB-positive observed All these biochemical histological parameters ameliorated Conclusion: HFD-induced obesity causes damage by oxidative inflammatory processes. may reduce stress inflammation play role obesity-related